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Sinonasal hemangiopericytomas. A clinicopathologic and DNA content study
A K el-Naggar1, J G Batsakis, G M Garcia
1Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Archives of Otolaryngology--Head & Neck Surgery
|February 1, 1992
Summary
Sinonasal hemangiopericytomas are typically low-grade neoplasms. Flow cytometry revealed diploid DNA patterns in most cases, correlating with favorable outcomes and controlled recurrences.
Area of Science:
- Oncology
- Pathology
Background:
- Sinonasal hemangiopericytomas are rare tumors.
- Understanding their biologic behavior is crucial for patient management.
Purpose of the Study:
- To present clinicopathologic and flow cytometric DNA characteristics of sinonasal hemangiopericytomas.
- To correlate DNA content with histomorphology and patient outcomes.
Main Methods:
- Retrospective analysis of 14 patients with sinonasal hemangiopericytomas.
- Flow cytometric DNA analysis to assess DNA ploidy and S-phase fraction.
- Histopathological review of tumor features and mitotic counts.
Main Results:
- Thirteen of 14 tumors showed a diploid DNA pattern with low S-phase.
- One tumor exhibited an aneuploid DNA pattern with high S-phase.
- Diploid tumors displayed uniform cellularity and low mitotic activity.
- All patients remained disease-free, with one experiencing a controlled recurrence.
Conclusions:
- Sinonasal hemangiopericytomas are generally low-grade neoplasms.
- Diploid DNA content and low S-phase are associated with favorable prognosis.
- Delayed recurrences are manageable, supporting conservative treatment approaches.