Tobramycin-impregnated methylmethacrylate for mandible reconstruction

Area of Science:

• Oral and Maxillofacial Surgery
• Biomaterials Science
• Surgical Reconstruction

Background:

• Mandibular defects require reconstruction to restore continuity and function.
• Traditional reconstruction methods may have limitations in infection control and defect adaptation.
• Methylmethacrylate (MMA) is a well-established biomaterial with excellent biocompatibility and mechanical properties.

Observation:

• A technique for fabricating tobramycin-impregnated methylmethacrylate implants during surgery was developed.
• Four cases of mandible reconstruction using these custom-fit implants were evaluated.
• The implants incorporate a potent antibiotic released over time to mitigate infection risk.

Findings:

• Three out of four patients demonstrated successful outcomes with the MMA implants.
• The material's ability to accurately fit complex defects was a key advantage.
• One patient experienced implant exposure after radiotherapy, necessitating removal.

Implications:

• Tobramycin-impregnated MMA implants offer a viable option for mandible reconstruction, potentially reducing postoperative infections.
• The technique's adaptability to various defect morphologies is beneficial.
• Further research may explore optimizing implant design and patient selection to minimize complications like exposure.