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Racemized D-aspartate in Alzheimer neurofibrillary tangles
G H Fisher1, I L Payan, S J Chou
1Department of Chemistry, University of Miami, Coral Gables, FL 33124.
Brain Research Bulletin
|January 1, 1992
Abstract:
Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo posttranslational modification by racemization to D-aspartate. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a greater number of these racemized D-aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.