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Stimulating erythropoiesis increases complement receptor expression on primate erythrocytes.

L A Hebert¹, D J Birmingham, X P Shen

¹Department of Internal Medicine, Ohio State University, Columbus 43210-1228.

Clinical Immunology and Immunopathology

|March 1, 1992

Summary

Stimulating red blood cell production, or erythropoiesis, by removing blood increases erythrocyte complement receptors (CR). This finding suggests a potential therapeutic strategy for immune complex diseases by boosting CR levels on red blood cells.

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Area of Science:

Immunology
Hematology
Primate Research

Background:

Erythrocyte complement receptors (CR) are crucial for clearing immune complexes from circulation.
Reduced erythrocyte CR levels are observed in immune complex-mediated diseases like SLE.
Younger erythrocytes express higher CR levels, suggesting erythropoiesis modulation as a therapeutic approach.

Purpose of the Study:

To investigate whether stimulating erythropoiesis increases the number of complement receptors (CR) per erythrocyte.
To test the hypothesis that enhanced red blood cell production can elevate erythrocyte CR expression.

Main Methods:

Erythropoiesis was stimulated in cynomolgus monkeys via weekly phlebotomy (removing 30% blood volume, discarding erythrocytes).
Control animals underwent sham phlebotomy with all blood components returned.

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Complement receptor levels per erythrocyte were measured over 8 weeks using flow cytometry.

Main Results:

Phlebotomy significantly increased the mean number of CR per erythrocyte (from 2780 to 4230, P < 0.0005).
This increase was sustained throughout the phlebotomy period and detected as early as 2 weeks.
A higher percentage of erythrocytes showed CR in clusters, indicating enhanced CR expression.

Conclusions:

Stimulating erythropoiesis effectively increases complement receptor expression on erythrocytes.
The observed increase in CR/erythrocyte is substantial and potentially biologically significant.
This suggests a novel therapeutic avenue for managing immune complex-mediated diseases.