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Related Experiment Videos

T cell vaccination in multiple sclerosis: a preliminary report.

D A Hafler1, I Cohen, D S Benjamin

  • 1Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Clinical Immunology and Immunopathology
|March 1, 1992
PubMed
Summary

This phase one trial explored using attenuated T cell clones for multiple sclerosis (MS). Inoculations were feasible in humans, showing no adverse effects and suggesting potential immunologic benefits for autoimmune disease treatment.

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Area of Science:

  • Neuroimmunology
  • Autoimmune Diseases
  • Clinical Trials

Background:

  • Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system.
  • Animal studies show attenuated T cell clones can prevent experimental autoimmune diseases.
  • This study explores T cell clone therapy in humans with MS.

Purpose of the Study:

  • To assess the feasibility of inoculating attenuated T cell clones in humans.
  • To investigate the immunologic effects of these inoculations.
  • To establish a foundation for future trials using autoreactive clones.

Main Methods:

  • A phase one clinical trial involving four subjects with progressive MS.
  • Seven inoculations were performed using attenuated, autologous T cell clones from cerebrospinal fluid.

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  • Immunologic studies monitored responses to T cell stimulation and mixed lymphocyte reactions.

    • Main Results:

    • No adverse side effects were observed during the inoculations.
    • Immunologic data indicated partial, short-term immunosuppression.
    • Observed effects included decreased CD2 pathway responses and increased autologous mixed lymphocyte response.

    Conclusions:

    • Inoculation with attenuated autoreactive T cell clones is feasible in humans.
    • This approach shows promise for clinical trials in autoimmune diseases.
    • Further research is warranted to explore therapeutic potential.