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Why do hemophiliacs bleed?

G J Broze1

  • 1Washington University School of Medicine, St. Louis.

Hospital Practice (Office Ed.)
|March 25, 1992
PubMed

A revised hypothesis of coagulation integrates all the factors known to be involved into a single pathway that is initiated by factor VIIa/tissue factor and in which "contact" factors are not required. A key point is that the initial hemostatic response must be "consolidated" by the progressive local generation of factor Xa and thrombin.

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