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Related Experiment Videos

Purine nucleotides.

G Burnstock

    Advances in Biochemical Psychopharmacology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Adenosine triphosphate (ATP) is identified as the primary neurotransmitter in nonadrenergic, noncholinergic (purinergic) nerves. This finding is supported by evidence of ATP synthesis, release, and its physiological effects mimicking nerve stimulation.

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    Area of Science:

    • Neuroscience
    • Autonomic Nervous System Physiology
    • Neurotransmission

    Background:

    • Nonadrenergic, noncholinergic (NAN) nerve components are integral to the autonomic nervous system.
    • These nerves are prevalent in the gastrointestinal tract and found in other organs like the lungs, bladder, and central nervous system.

    Purpose of the Study:

    • To establish Adenosine Triphosphate (ATP) as the principal neurotransmitter released by nonadrenergic, noncholinergic (purinergic) nerves.
    • To elucidate the physiological role and transmission properties of these nerves.

    Main Methods:

    • Investigated ATP synthesis, storage, and release from stimulated nerves.
    • Examined the effects of exogenously applied ATP on K+ conductance.
    • Assessed the role of ATP-inactivating enzymes (ATPase, 5'nucleotidase, adenosine deaminase).

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  • Evaluated drug effects on responses to exogenous ATP and nerve stimulation.

    • Main Results:

    • Evidence confirms ATP is synthesized, stored, and released by stimulated NAN nerves.
    • Exogenous ATP application mimics nerve-released transmitter effects, increasing K+ conductance.
    • Specific enzymes inactivate released ATP.
    • Certain drugs modulate responses to both exogenous ATP and nerve stimulation.

    Conclusions:

    • Adenosine triphosphate (ATP) is strongly supported as the neurotransmitter in nonadrenergic, noncholinergic (purinergic) nerves.
    • The physiological actions of these nerves are mediated by ATP release and subsequent inactivation by specific enzymes.