Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Can non-REM sleep be depressogenic?

D G Beersma1, R H van den Hoofdakker

  • 1Department of Biological Psychiatry, University Hospital, Groningen, Netherlands.

Journal of Affective Disorders
|February 1, 1992
PubMed
Summary

Sleep manipulations, like deprivation, show antidepressant effects in major depression. Findings suggest reduced non-REM sleep intensity is the key mechanism, impacting mood regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Will light brighten the future of the depressed patient?

Acta neuropsychiatrica·2016
Same author

Spectral analysis of the sleep EEG of depressed patients before and after total sleep deprivation.

Acta neuropsychiatrica·2016
Same author

The prevalence of seasonal affective disorder (SAD) in The Netherlands.

Acta neuropsychiatrica·2016
Same author

A longitudinal study of sleep deprivation responses in depression; The variability is highly related to diurnal mood variability.

Acta neuropsychiatrica·2016
Same author

Attunement of non-verbal behaviour between depressed patients and a psychiatrist at admission is related to persistence of depression.

Acta neuropsychiatrica·2016
Same author

Models of human sleep regulation.

Sleep medicine reviews·2004

Area of Science:

  • Neuroscience
  • Psychiatry
  • Sleep Medicine

Background:

  • Sleep disturbances and mood disorders, particularly major depression, are closely linked.
  • Previous research indicates various sleep manipulations (e.g., deprivation, temporal shifts) yield antidepressant effects.

Purpose of the Study:

  • To investigate the underlying mechanisms of antidepressant effects observed in sleep manipulation experiments.
  • To evaluate prevailing hypotheses regarding REM sleep versus non-REM sleep suppression.

Main Methods:

  • Review and synthesis of existing experimental data on sleep deprivation and its impact on mood.
  • Analysis of the kinetics of non-REM sleep intensity and REM sleep production.
  • Examination of the interaction between non-REM and REM sleep phases.

Main Results:

  • Experimental data consistently show antidepressant effects from sleep manipulations.
  • The suppression of non-REM (non-Rapid Eye Movement) sleep intensity emerges as a significant factor.
  • Interaction dynamics between REM (Rapid Eye Movement) and non-REM sleep are crucial.

Conclusions:

  • The suppression of non-REM sleep intensity is proposed as the common pathway for antidepressant effects seen in sleep manipulation studies.
  • This finding offers a unified explanation for diverse experimental results in sleep and depression research.

Related Experiment Videos