Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Second-order approximations for selection coefficients at polygenic loci. II. Pleiotropy.

A Hastings1

  • 1Division of Environmental Studies, University of California, Davis 95616.

Journal of Mathematical Biology
|January 1, 1992
PubMed
Summary

This study develops a second-order approximation for quantitative trait distributions under selection. The new formulae improve upon existing models for genetic selection, offering greater accuracy for complex traits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low risk management intervention: Limited impact of remedial tillage on net ecosystem carbon balance at a commercial Miscanthus plantation.

Global change biology. Bioenergy·2024
Same author

Critical review of the impacts of grazing intensity on soil organic carbon storage and other soil quality indicators in extensively managed grasslands.

Agriculture, ecosystems & environment·2018
Same author

Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ASK8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study.

Annals of the rheumatic diseases·2011
Same author

Near-patient platelet function testing in patients undergoing coronary artery surgery: a pilot study.

Anaesthesia·2011
Same author

Chaos and scale.

Trends in ecology & evolution·2011
Same author

Genetic and evolutionary consequences of metapopulation structure.

Trends in ecology & evolution·2011

Area of Science:

  • Quantitative Genetics
  • Statistical Genetics
  • Evolutionary Biology

Background:

  • Understanding the phenotypic distribution of quantitative traits is crucial for predicting evolutionary responses to selection.
  • Existing models often simplify genetic architectures, neglecting nuances in trait distributions and selection effects.
  • Accurate formulae for selection effects are needed, especially for complex traits influenced by multiple factors.

Purpose of the Study:

  • To derive a second-order approximation for the phenotypic distribution of multiple quantitative traits.
  • To develop new formulae for single-locus selection effects under stabilizing and correlated truncation selection.
  • To provide a more accurate theoretical framework for genetic selection analyses.

Main Methods:

Related Experiment Videos

  • Developed a second-order approximation for phenotypic distributions, conditioned on specific genotypes.
  • Derived formulae for selection effects under random mating, Gaussian stabilizing selection, and correlated truncation selection.
  • Analyzed the approximation's error, demonstrating it to be third-order in allelic/genotypic effects.

    • Main Results:

    • The derived formulae apply to arbitrary phenotypic distributions and include corrections to standard models (e.g., Falconer, 1989).
    • The second-order approximation for phenotypic distributions conditioned on a single allele was also validated.
    • Approximations are consistent, yielding identical results whether based on genotypic deviations or average allelic effects.

    Conclusions:

    • The novel second-order approximation offers improved accuracy for modeling phenotypic distributions under selection.
    • The refined formulae enhance predictions of evolutionary change in quantitative traits.
    • This work provides a more robust theoretical foundation for quantitative genetic studies.