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Ten-year survivors with multiple myeloma
H Murakami1, K Nemoto, S Miyawaki
1Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
Journal of Internal Medicine
|February 1, 1992
Summary
Long-term survival in multiple myeloma is rare, occurring in 6.9% of Japanese patients. Factors like younger age and specific chemotherapy treatments improved survival outcomes.
Area of Science:
- Hematology
- Oncology
Background:
- Multiple myeloma is a cancer of plasma cells.
- Long-term survival data for multiple myeloma patients are crucial for treatment planning.
Purpose of the Study:
- To identify factors associated with long-term survival in Japanese multiple myeloma patients.
Main Methods:
- Retrospective analysis of 130 Japanese patients with symptomatic multiple myeloma treated between 1970 and 1989.
- Correlation analysis to identify factors linked to survival exceeding 10 years.
Main Results:
- Nine out of 130 patients (6.9%) survived for over 10 years.
- Younger age, low/intermediate tumor burden, cyclophosphamide chemotherapy, myeloma protein disappearance, and positive retreatment response correlated with longer survival.
Conclusions:
- Certain factors significantly correlate with long-term survival in multiple myeloma.
- These findings can inform treatment strategies for improving patient prognosis.