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Hemorrhaging at menarche: a case report.

C L Ward

The Journal of Family Practice

|March 1, 1992

Summary

This summary is machine-generated.

A 12-year-old girl experienced severe bleeding at menarche, diagnosed with von Willebrand

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Area of Science:

Hematology
Genetics
Pediatric Medicine

Background:

Von Willebrand's disease (VWD) is an inherited bleeding disorder.
Type 1 VWD is the most common subtype, characterized by reduced levels of von Willebrand factor.
Menarche can unmask or exacerbate bleeding disorders in adolescent females.

Observation:

A 12-year-old female presented with significant hemorrhaging at menarche.
The patient had a prior history of severe epistaxis (nosebleeds).
Multiple blood transfusions were required to manage the acute bleeding episode.

Findings:

Bleeding studies confirmed the diagnosis of type 1 von Willebrand's disease.
Genetic screening of the patient's three siblings revealed they also tested positive for type 1 VWD.

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Implications:

Early diagnosis and management of VWD are crucial, especially in adolescent females.
Family screening is essential for identifying other affected individuals with inherited bleeding disorders.
Understanding the presentation of VWD is vital for pediatricians and hematologists.