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Related Experiment Videos

Exercise and food restriction in rats.

J O Holloszy1

  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.

The Journal of Nutrition
|March 1, 1992
PubMed
Summary
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Exercise in rats increases average survival but not maximal lifespan. Food restriction extends lifespan, and while exercise negatively impacts food-restricted rats initially, it doesn't negate lifespan extension benefits.

Area of Science:

  • Gerontology
  • Exercise Physiology
  • Nutritional Science

Background:

  • Studies indicate exercise in rats improves average survival compared to sedentary controls.
  • The impact of exercise on maximal lifespan remains debated.
  • Food restriction is known to extend lifespan in rodents.

Purpose of the Study:

  • To investigate the effects of voluntary wheel running on maximal lifespan in male Long-Evans rats.
  • To compare the longevity effects of exercise alone, food restriction alone, and a combination of both.
  • To determine if exercise can counteract or enhance the lifespan-extending effects of food restriction.

Main Methods:

  • Male specific-pathogen-free Long-Evans rats were subjected to voluntary wheel running (exercise).
  • Separate groups were subjected to food restriction (approx. 30% below ad libitum intake).

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  • A combined group underwent both voluntary wheel running and food restriction.

    • Main Results:

    • Exercise alone increased average survival but did not extend maximal lifespan compared to sedentary controls.
    • Food restriction extended lifespan and increased maximal lifespan.
    • Combined exercise and food restriction showed increased early mortality, but survivors past 900 days had similar survival curves and maximal lifespan to food-restricted sedentary controls.
    • Exercise had a deleterious effect on food-restricted rats in the initial phase of life.

    Conclusions:

    • Voluntary wheel running in rats enhances average survival but does not increase maximal lifespan.
    • Food restriction significantly extends lifespan and maximal lifespan.
    • While exercise negatively impacts food-restricted rats initially, it does not abolish the lifespan-extending benefits of food restriction.