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Oxaflozane overdose in a child.

J P Dutertre1, P Barbier, A L Suc

  • 1Department of Clinical Pharmacology, Centre Hospitalier Régional et Universitaire de Tours, France.

Journal of Toxicology. Clinical Toxicology
|January 1, 1992
PubMed
Summary

A severe poisoning case in a 2-year-old child treated with oxaflozane, a non-tricyclic antidepressant, resulted in recovery via conservative measures. This highlights the importance of prompt medical intervention for antidepressant overdose in pediatric patients.

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Area of Science:

  • Toxicology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Oxaflozane is a non-tricyclic antidepressant.
  • Antidepressant poisoning in children is a serious concern.
  • Understanding the toxicokinetics of oxaflozane is crucial for management.

Observation:

  • A 2-year-old child ingested 150 mg of oxaflozane.
  • The child experienced loss of consciousness, opisthotonos, and coma.
  • Atropine-like symptoms were observed during the poisoning episode.

Findings:

  • Conservative treatment led to the child's recovery.
  • Maximal plasma concentration of oxaflozane reached 63 ng/mL.
  • The elimination half-life of N-dealkyloxaflozane was determined to be 4.8 hours.

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Implications:

  • This case underscores the potential toxicity of oxaflozane in pediatric populations.
  • Conservative management can be effective in treating severe oxaflozane poisoning.
  • Further research into pediatric antidepressant toxicity is warranted.