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Ibuprofen overdose in adults.

A H Hall¹, S C Smolinske, B Stover

¹Rocky Mountain Poison and Drug Center, Denver, Colorado.

Journal of Toxicology. Clinical Toxicology

|January 1, 1992

Summary

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Ibuprofen overdose in adults rarely causes serious toxicity. Renal function tests are not routinely needed for ingestions under 6 grams, and 4 hours of observation suffices for asymptomatic patients.

Area of Science:

Toxicology
Pharmacokinetics
Clinical Medicine

Background:

Ibuprofen overdose management guidelines require further clarification.
Assessing the risk of renal injury and central nervous system (CNS) toxicity is crucial.

Purpose of the Study:

To determine the incidence of renal injury in ibuprofen overdose cases.
To evaluate the utility of timed plasma ibuprofen levels in patient management.

Main Methods:

Prospective study of 63 adult ibuprofen overdose cases.
Analysis of timed plasma ibuprofen levels and comparison with a nomogram.
Monitoring for central nervous system (CNS) and renal toxicity.

Main Results:

No serious toxicity was observed in any cases.

Related Experiment Videos

Ingestion of less than 3 grams of ibuprofen did not result in significant CNS or other toxicity.

Two patients ingesting 4 and 4.8 grams had minor blood urea nitrogen elevations despite normal serum creatinine.

A revised nomogram may aid in predicting outcomes for asymptomatic patients.

Conclusions:

Renal function tests are not routinely indicated for ibuprofen ingestions under 6 grams.
Four hours of observation is adequate for asymptomatic patients not requiring psychiatric admission.
Timed plasma ibuprofen levels are not necessary for effective patient management in overdose cases.