Effect of low amphetamine doses on cardiac responses to emotional stress in aged rats

In young Wistar rats conditioned emotional stress can be characterized by a learned bradycardiac response to an inescapable footshock. In aged rats this bradycardiac response is attenuated and accompanied by suppressed behavioral arousal in response to novelty. In the present study, cardiac responses to emotional stress and behavioral reactivity to a novel experience in an open field were tested in aged and young rats under the influence of a low dose of d-amphetamine (AMPH, 0.5 mg/kg IP). AMPH administration in 27-month-old rats reinstated the bradycardiac response to emotional stress, while it failed to influence the resting heart rate in the home cage. Age-associated differences in open-field ambulation, present in drug-free conditions, were antagonized by low doses of AMPH (0.25-1.0 mg/kg). It is concluded that enhanced arousal by aminergic stimulation with AMPH in the aged rat invoked cardiac and behavioral response patterns resembling those at younger ages.