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Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys
1Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.
Neuroscience Letters
|January 20, 1992
Abstract:
A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.