Related Experiment Video
Updated: Aug 17, 2026

Measurement of Antibody Effects on Cellular Function of Isolated Cardiomyocytes
Published on: March 8, 2013
Unusual cardiovascular localization of nonamyloid immunoglobulin deposition disease causing sudden death
1University of Ottawa Heart Institute, Department of Anatomical Pathology, Ottawa Civic Hospital, Canada.
Abstract:
The case of a 38-yr-old man is presented in whom sudden death was attributed to coronary ostial stenosis caused by aortic intimal deposits of an amyloid-like material. Autopsy revealed wide-spread lymphocytic lymphoma with kappa light chain restriction. Histochemistry, immunoperoxidase light microscopy, transmission electron microscopy, and immunoelectron microscopy identified the coronary ostial, and massive other cardiovascular, deposits as para-amyloid of kappa light chain origin.
Related Concept Videos
Myocarditis I: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Rheumatic Heart Disease I: Introduction
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy IV: Restrictive Cardiomyopathy

