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Baclofen effect on quadriceps strength in multiple sclerosis.

M B Smith1, S P Brar, L M Nelson

  • 1Department of Rehabilitation Medicine, University of Colorado, Denver.

Archives of Physical Medicine and Rehabilitation
|March 1, 1992
PubMed
Summary
This summary is machine-generated.

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Baclofen did not significantly alter quadriceps strength in multiple sclerosis patients. Reported weakness may stem from a subjective perception of reduced stiffness rather than actual loss of contractile force.

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Pharmacology

Background:

  • Baclofen is a muscle relaxant commonly prescribed for spasticity.
  • Patient-reported weakness is a known side effect of baclofen.
  • Understanding the physiological basis of baclofen-induced weakness is crucial for patient management.

Purpose of the Study:

  • To objectively assess the effect of baclofen on muscle strength.
  • To investigate the relationship between baclofen use and subjective reports of weakness in multiple sclerosis patients.

Main Methods:

  • Thirty participants with multiple sclerosis and mild to moderate spasticity were enrolled.
  • A standardized baclofen titration protocol was administered over seven days, reaching a maintenance dose of 20mg.
  • Maximal concentric quadriceps contractions were measured using isokinetic dynamometry (KinCom) at 60 degrees/second.

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Main Results:

  • No significant difference was observed in maximum torque production before and after baclofen treatment.
  • The angle at which peak torque occurred shifted towards normal values, indicating improved muscle function parameters.
  • Subjective reports of weakness did not correlate with objective measures of contractile strength.

Conclusions:

  • Baclofen, at a dose of 20mg, does not appear to impair quadriceps muscle strength in multiple sclerosis patients.
  • Subjective weakness experienced by patients may be a misinterpretation of reduced muscle stiffness.
  • Further research is needed to explore the nuances of baclofen's effects on spasticity and patient-reported outcomes.