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Cholecystokinin-induced c-fos expression in the rat brain stem is influenced by vagal nerve integrity
1Department of Medical Physiology, University of Calgary, Alberta, Canada.
Experimental Physiology
|January 1, 1992
Abstract:
Exogenous cholecystokinin (CCK) activates brain stem neurons in the area postrema and nucleus of the tractus solitarius, primarily in regions where vagal afferent fibres terminate. The present experiments show that vagal sensory fibres mediate CCK-induced c-fos in brain stem neurons, based on the findings that perivagal capsaicin pre-treatment in seven out of eight cases reduced or ablated c-fos expression in these regions.