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Gastrointestinal disorders in rheumatic diseases.

A L Parke1

  • 1University of Connecticut Health Center, Farmington.

Current Opinion in Rheumatology
|February 1, 1992
PubMed
Summary

Bacterial or dietary antigens crossing a diseased bowel can cause chronic, extraintestinal autoimmune diseases. Treating the underlying bowel condition may resolve these issues, but identifying the initial cause is often difficult.

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Area of Science:

  • Gastroenterology and Immunology
  • Rheumatology

Background:

  • Diseased bowel walls can allow antigen exposure, leading to chronic, extraintestinal, and autoimmune conditions.
  • Inflammatory bowel diseases (IBD) pose challenges in identifying the primary etiology of bowel disorders.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), while crucial for rheumatologic complaints, can cause significant gastrointestinal damage.

Purpose of the Study:

  • To explore the link between bowel disease, antigen exposure, and extraintestinal manifestations.
  • To highlight the diagnostic challenges in inflammatory bowel diseases.
  • To discuss the gastrointestinal risks associated with NSAID use in treating rheumatologic conditions.

Main Methods:

  • Review of existing literature on antigen exposure and extraintestinal disease.
  • Analysis of the role of inflammatory bowel diseases in chronic conditions.
  • Examination of the adverse effects of nonsteroidal anti-inflammatory drugs on the gastrointestinal tract.

Main Results:

  • Antigen persistence at extraintestinal sites can sustain chronic and autoreactive diseases.
  • Effective treatment of bowel disease can resolve associated extraintestinal symptoms.
  • NSAIDs can induce gastrointestinal disease potentially more severe than previously understood.

Conclusions:

  • Understanding antigen translocation is key to managing extraintestinal complaints linked to bowel disorders.
  • Further research is needed to identify the etiologies of inflammatory bowel diseases.
  • The gastrointestinal risks of NSAIDs necessitate a re-evaluation of current arthritis treatment strategies.

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