Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug therapy during pregnancy.

J R Niebyl1

  • 1University of Iowa Hospitals and Clinics, Iowa City.

Current Opinion in Obstetrics & Gynecology
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Folic acid supplementation significantly reduces neural tube defect recurrence. Several medications, including ACE inhibitors and indomethacin, pose risks during pregnancy, while others like Vitamin B6 and ginger can alleviate nausea.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Folate, zinc, and vitamin B-12 intake during pregnancy and postpartum.

Journal of the American Dietetic Association·2001
Same author

Pharmacogenetic screening for susceptibility to fetal malformations in women.

The Annals of pharmacotherapy·2000
Same author

Methotrexate and misoprostol to terminate early pregnancy.

The New England journal of medicine·1996
Same author

Use of antibiotics for ear, nose, and throat disorders in pregnancy and lactation.

American journal of otolaryngology·1992
Same author

Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor.

American journal of obstetrics and gynecology·1991
Same author

Drug therapy during pregnancy.

Current opinion in obstetrics & gynecology·1991

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Pharmacology in Pregnancy

Background:

  • Neural tube defects (NTDs) pose a significant risk, especially with a history of affected child.
  • Various medications are used during pregnancy, but their safety and efficacy profiles vary.
  • Maternal conditions like preeclampsia and epilepsy require careful management during gestation.

Purpose of the Study:

  • To evaluate the efficacy of folic acid in preventing recurrent NTDs.
  • To assess the risks and outcomes associated with specific medications during pregnancy.
  • To determine effective treatments for common pregnancy-related issues like nausea and seizures.

Main Methods:

  • Randomized prospective trial for folic acid intervention.
  • Long-term follow-up of infants exposed to antiepileptic drugs in utero.

Related Experiment Videos

  • Comparative effectiveness studies for seizure prevention and tocolysis.
  • Observational data on medication effects on fetal and neonatal outcomes.

    • Main Results:

    • Folic acid reduced NTD recurrence by 72% in high-risk women.
    • Carbamazepine has a 1% risk of spina bifida; no long-term neurodevelopmental differences noted between phenobarbital and carbamazepine exposure.
    • Magnesium sulfate is superior to phenytoin for eclamptic seizure prevention.
    • Vitamin B6 and ginger effectively manage nausea; low-dose aspirin ineffective post-preeclampsia diagnosis.
    • ACE inhibitors cause renal dysfunction; beta-adrenergic agents fail to prevent prematurity in twins.
    • Indomethacin increases risk of pulmonary hypertension; lithium can cause polyhydramnios.
    • Erythromycin treatment for Ureaplasma urealyticum shows no improvement in perinatal outcomes.

    Conclusions:

    • Periconceptional folic acid is crucial for preventing NTD recurrence.
    • Careful consideration of medication risks and benefits is essential during pregnancy.
    • Specific interventions show promise for managing pregnancy complications, while others lack efficacy or pose risks.