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Updated: Sep 4, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Neonatal and infant care and outcomes
1Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Insights
Surfactant replacement therapy improves neonatal survival, especially for extremely low birth weight infants. Further research is needed on survival rates by gestational age and assessment methods.
Area of Science:
- Neonatal care and Perinatology
- Clinical trials and Evidence-based medicine
Background:
- Surfactant replacement therapy represents a significant advancement in neonatal intensive care.
- Over 30 clinical trials support its efficacy, leading to widespread approval.
- Ongoing research aims to fully determine its clinical application and impact on patient outcomes.
Purpose of the Study:
- To analyze current neonatal outcome data and identify areas for improved survival.
- To address the need for clarity regarding survival rates in specific low gestational age cohorts.
- To highlight the importance of accurate gestational age assessment in neonatal care.
Main Methods:
- Review of neonatal outcome data from clinical trials and observational studies.
- Analysis of survival statistics stratified by birth weight and gestational age.
- Examination of methodologies for assessing gestational age in neonates.
Main Results:
- Neonatal survival improvements are now predominantly focused on extremely low birth weight infants (<750 g).
- There is a recognized need for more precise data on survival for infants born before 28 weeks of gestation.
- Understanding the nuances of gestational age assessment is crucial for accurate outcome interpretation.
Conclusions:
- Surfactant therapy has transformed neonatal care, with survival gains now centering on the most vulnerable infants.
- Accurate gestational age determination is critical for evaluating neonatal outcomes and guiding clinical practice.
- Further research should focus on optimizing care for preterm infants and refining assessment techniques.
Abstract:
A major advance in neonatal care, surfactant replacement therapy, has received wide endorsement and approval after being subject to over 30 clinical trials. Details of clinical application and full impact on outcomes are in the process of being determined. Neonatal outcome data indicate that the focus of improvement in survival now rests primarily on the extremely low birth weight (less than 750 g) infant. There is additional need for clarity of actual survival by gestational age in the less-than-28-week cohort. The differences and limitations of neonatal and obstetric methods of gestational age assessment are important. Significant contributions to our knowledge of problems such as retinopathy of prematurity, syphilis, and infants of diabetic mothers have recently appeared.
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