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Isolation and partial characterization of molecular forms of ceruloplasmin from human bile
I A Verbina1, L V Puchkova, V S Gaitskhoki
1Institute for Experimental Medicine, USSR Academy of Medical Sciences, Saint Petersburg.
FEBS Letters
|February 24, 1992
Abstract:
Highly purified ceruloplasmin (CP) was isolated from human bile using affinity chromatography. Biliary CP is represented by two molecular species. One of those is identical to oxidase CP from normal human serum while the other is analogous to oxidase-lacking CP specific for the serum of the carriers of Wilson's mutation with respect to immunological specificity, electrophoretical mobility and molecular mass of the large fragments from spontaneous proteolysis.