Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A universal compositional correlation among codon positions.

G D'Onofrio1, G Bernardi

  • 1Laboratoire de Génétique Moleculaire, Institut Jacques Monod, Paris, France.

Gene
|January 2, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synonymous codon choices in the extremely GC-poor genome of Plasmodium falciparum: compositional constraints and translational selection.

Journal of molecular evolution·1999
Same author

Presynaptic muscarinic (M3) receptors reduce excitatory transmission in dopamine neurons of the rat mesencephalon.

Neuroscience·1999
Same author

[Video-assisted extensive thymectomy in the treatment of autoimmune myasthenia].

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna·1999
Same author

A mixed D1 and D2 antagonist does not replay pattern electroretinogram alterations observed with a selective D2 antagonist in normal humans: relationship with Parkinson's disease pattern electroretinogram alterations.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·1999
Same author

Neuroprotective effects of riluzole: an electrophysiological and histological analysis in an in vitro model of ischemia.

Synapse (New York, N.Y.)·1999
Same author

Electrophysiological recordings and calcium measurements in striatal large aspiny interneurons in response to combined O2/glucose deprivation.

Journal of neurophysiology·1999
Same journal

Face/off: phase-specific modeling of lineage plasticity using near-patient models in genitourinary cancers.

Gene·2026
Same journal

Hierarchical analysis of metabolic phenotype reveals distinct microbiota and circulatory transcriptome in metabolic dysfunction-associated steatotic liver disease.

Gene·2026
Same journal

Mutation T71R enhanced the structural stability and functional activity of wild type superoxide dismutase cloned from soil metagenome.

Gene·2026
Same journal

Reduced ATXN1 expression as an adverse prognostic indicator in Acute myeloid leukemia.

Gene·2026
Same journal

Constructing regulatory networks of Rubisco post-translational modifications: a novel avenue for engineering environment adaptive plants.

Gene·2026
Same journal

Traumatic brain injury enhances fracture healing by upregulating VNN1 to activate the Wnt/β-catenin signaling pathway.

Gene·2026
See all related articles

This study analyzed gene codon composition in prokaryotes and eukaryotes. A universal correlation was found between codon positions, driven by consistent compositional constraints across diverse genomes.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Gene composition varies across different organisms.
  • Understanding codon usage patterns is crucial for evolutionary and functional genomics.

Purpose of the Study:

  • To investigate the compositional distributions of third codon positions in prokaryotic and eukaryotic genes.
  • To explore the correlations between codon positions across diverse genomes.
  • To identify universal principles governing gene composition.

Main Methods:

  • Analysis of coding sequences from large public databases.
  • Statistical examination of guanine-cytosine (GC) content at different codon positions.
  • Comparative analysis across 16 prokaryotic and 7 eukaryotic species, with an expanded prokaryotic set.

Related Experiment Videos

Main Results:

  • Prokaryotic genomes showed both narrow and broad compositional distributions.
  • Eukaryotic genomes exhibited broad distributions, differing significantly between species (except Saccharomyces cerevisiae).
  • A universal correlation was identified between third codon positions and the combined first + second codon positions across all investigated genomes.

Conclusions:

  • Compositional constraints on codon positions exhibit a consistent relative effect across prokaryotic and eukaryotic genomes.
  • This universality suggests fundamental biological principles underlying gene sequence composition.
  • The findings provide insights into genome evolution and the selective pressures shaping gene sequences.