Neuroleptic malignant syndrome associated with metoclopramide antiemetic therapy

A case of neuroleptic malignant syndrome in a 50-year-old woman with ovarian cancer is reported. The syndrome was associated with metoclopramide antiemetic therapy given for post-operative nausea and vomiting. Dantrolene, bromocriptine, and supportive measures were effective in obtaining a complete resolution of the syndrome. This potentially lethal syndrome is perhaps underreported in the gynecologic literature. Heightened awareness of its signs and symptoms may cause more cases to be recognized and help improve its outcome.