Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Targeted alpha therapy for cancer.

Barry J Allen1, Chand Raja, Syed Rizvi

  • 1Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Kogarah 2217, NSW, Australia.

Physics in Medicine and Biology
|September 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary fibrosis after COVID-19 is characterized by airway abnormalities and elevated club cell secretory protein-16.

JCI insight·2026
Same author

Signal in the Noise: Polygenic Scores and the Problem of Defining Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine·2026
Same author

Progressive Fusion of Multi-Scale Mamba Context and Local Detail Priors for Infrared Small Target Detection.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2026
Same author

Performance of Age-Adjusted Whole Genome Sequencing Telomere Length in Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine·2026
Same author

Publisher Correction: Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.

Genome biology·2026
Same author

Optical Coherence Tomography Biomarkers Differentiate Epiretinal Membranes Secondary to Retinal Detachment from Idiopathic Epiretinal Membranes.

Journal of vitreoretinal diseases·2026

Targeted alpha therapy (TAT) shows promise in inhibiting cancer micrometastases. This study demonstrates TAT

Area of Science:

  • Oncology
  • Radiochemistry
  • Cancer Biology

Background:

  • Targeted alpha therapy (TAT) utilizes alpha-emitting radioisotopes for cancer treatment.
  • Micrometastases and preangiogenic cancer cell clusters are challenging therapeutic targets.
  • Bismuth-213 (Bi-213) eluted from Actinium-225 (Ac-225) generators is a key radioisotope for TAT.

Purpose of the Study:

  • To evaluate the practicality and efficacy of targeted alpha therapy (TAT).
  • To assess TAT's potential in inhibiting micrometastases and preangiogenic cancer cell clusters.
  • To investigate TAT in various cancer types including melanoma, leukemia, colorectal, breast, prostate, and pancreatic cancers.

Main Methods:

  • In vitro and in vivo studies were conducted using alpha-conjugates (ACs) comprising Bi-213 chelated to cancer-specific monoclonal antibodies or proteins.

Related Experiment Videos

  • Cytotoxicity and specificity of ACs were tested against multiple human cancer cell lines.
  • Tumor growth inhibition was assessed in mouse models following local and systemic administration of ACs.
  • A phase 1 clinical trial involving intralesional TAT for advanced melanoma patients was performed.

    • Main Results:

    • In vitro studies demonstrated that TAT is significantly more cytotoxic to targeted cells compared to non-specific conjugates or free isotopes.
    • In vivo local TAT completely prevented tumor formation in multiple cancer models when administered early post-inoculation.
    • Intra-lesional TAT demonstrated complete regression of advanced melanoma and significant inhibition of breast and prostate cancer growth.
    • The phase 1 clinical trial confirmed that intralesional TAT can induce tumor regression in melanoma patients with no observed complications.

    Conclusions:

    • Targeted alpha therapy (TAT) is a highly effective strategy for inhibiting cancer cell growth, particularly micrometastases.
    • Both local and systemic administration of TAT show significant therapeutic potential across various cancer types.
    • Clinical trials indicate that TAT is a safe and effective treatment modality for advanced melanoma, supporting its application in cancer management.