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Periodic adhesive fingers between contacting cells.

H Delanoë-Ayari1, P Lenz, J Brevier

  • 1Laboratoire de spectrométrie physique (CNRS), UMR 5588, Université Joseph Fourier, Saint-Martin d'Hères, France.

Physical Review Letters
|September 28, 2004
PubMed
Summary
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Cellular "fingers" form in adherens junctions due to cadherin interactions and actin growth. Membrane tension limits finger growth, with shapes and kinetics matching theoretical models.

Area of Science:

  • Cell Biology
  • Biophysics
  • Adhesion Dynamics

Background:

  • Adherens junctions mediate cell-cell adhesion.
  • Periodic patterns, termed
  • fingers
  • , emerge at cell-cell contacts.
  • These structures break contact symmetry.

Purpose of the Study:

  • Investigate the properties of cellular "fingers".
  • Identify the molecular drivers of finger formation.
  • Develop and validate a theoretical model for finger growth.

Main Methods:

  • Experimental measurement of finger shape and formation kinetics.
  • Theoretical modeling of finger growth dynamics.
  • Analysis of cadherin interactions and actin polymerization.

Related Experiment Videos

Main Results:

  • Finger formation is driven by cadherin interactions and actin growth.
  • Membrane tension acts as a limiting factor for finger elongation.
  • Experimental data aligns with theoretical predictions for finger shape and kinetics.

Conclusions:

  • Cellular fingers are a result of interplay between molecular forces and physical constraints.
  • The study provides a quantitative understanding of these complex cell-cell adhesion structures.
  • The developed model accurately describes finger formation and steady-state morphology.