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Updated: Jul 24, 2026

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
Published on: November 2, 2011
Periodic adhesive fingers between contacting cells
H Delanoë-Ayari1, P Lenz, J Brevier
1Laboratoire de spectrométrie physique (CNRS), UMR 5588, Université Joseph Fourier, Saint-Martin d'Hères, France.
Abstract:
We study in detail the properties of fingers, a particular type of cell-cell adhesive structures appearing in adherens junctions. These periodic patterns break the symmetry of cell-cell contacts. We show that finger formation is driven by cadherin interactions and actin growth. A theoretical model is introduced in which the growth of fingers is limited by membrane tension. The steady shape and formation kinetics of fingers are experimentally measured and compared with the theoretical predictions.
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