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Circulating immune complexes in acute uveitis: a possible association with the histocompatibility complex locus
International Archives of Allergy and Applied Immunology
|January 1, 1979
Summary
Circulating immune complexes (ICs) may play a role in acute anterior uveitis pathogenesis, particularly in patients negative for the human leukocyte antigen B27 (HLA-B27). This finding offers insights into uveitis development beyond HLA-B27 association.
Area of Science:
- Ophthalmology
- Immunology
- Genetics
Background:
- Acute anterior uveitis is an inflammatory eye condition.
- The human leukocyte antigen B27 (HLA-B27) is strongly associated with acute anterior uveitis.
- The role of immune complexes (ICs) in this condition is not fully understood.
Purpose of the Study:
- To investigate the presence of circulating immune complexes (ICs) in patients with acute anterior uveitis.
- To explore the correlation between ICs and HLA-B27 status in these patients.
Main Methods:
- Investigated 39 patients with acute anterior uveitis.
- Utilized multiple techniques to detect circulating ICs, including rheumatoid factor and complement activation.
- Assessed neutrophil chemotactic index (NCI) in plasma.
Main Results:
- Immune complexes (ICs) were detected in patients with acute anterior uveitis.
- ICs were found more frequently in patients who were HLA-B27 negative.
- Neutrophil chemotactic index (NCI) was also evaluated.
Conclusions:
- Circulating immune complexes (ICs) may contribute to the pathogenesis of acute anterior uveitis.
- This involvement appears particularly significant in HLA-B27 negative individuals.
- Findings suggest IC deposition as a potential mechanism in non-HLA-B27 associated uveitis.