Related Experiment Video
Updated: Aug 21, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024
Familial hemiplegic migraine, neuropsychiatric symptoms, and Erdheim-Chester disease
David F Black1, Simon Kung, Christopher L Sola
1Mayo Clinic, Neurology, Rochester, MN 55905, USA.
Abstract:
We report the occurrence of unilateral cerebral hemisphere edema with subsequent cortical laminar necrosis in the setting of familial hemiplegic migraine (FHM) and permanent neurologic sequelae after resolution of an attack in 1 patient. Contemporaneous with this severe attack of FHM, the patient was found to exhibit multiple systemic and neurological symptoms referable to Erdheim-Chester disease (a rare non-Langerhans cell histiocytosis) that was confirmed by bone biopsy. This case demonstrates the severity possible with a migrainous infarction associated with FHM. The co-occurrence of two such rare entities in 1 patient suggests a possible relationship.
Related Concept Videos
Encephalitis l: Introduction
Hepatic Encephalopathy
Huntington Disease l: Introduction
Encephalitis ll: Pathophysiology
Multiple Sclerosis l: Introduction
Dementia l: Introduction
