How to come up with a good research question: framing the hypothesis

Having a questioning attitude is the fist step in the research process. Research begins with a question, which leads to a hypothesis. Questions abound in our daily clinical lives. Most quality research consists of comparisons. By carefully selecting a comparison group or condition, the quality of the research project can be improved. By including in the hypothesis the comparison group, the experiment can be focused and the analysis simplified. The best questions come from the investigator's subject of interest. When starting a research project, start small and choose an experienced mentor.