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Bacterial patterns found in surgery patients with chronic sinusitis
The Journal of the American Osteopathic Association
|February 1, 1992
Summary
For chronic sinusitis, common aerobic bacteria like Staphylococcus and Streptococcus were identified. Newer antibiotics such as ciprofloxacin and cefuroxime axetil showed better effectiveness than older drugs like penicillin G.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Chronic sinusitis is a common condition often treated empirically with oral antibiotics.
- Understanding the prevalent aerobic bacterial pathogens and their antibiotic susceptibilities is crucial for effective treatment.
Purpose of the Study:
- To identify aerobic bacteria commonly isolated from patients undergoing sinus surgery for chronic sinusitis.
- To compare the in vitro susceptibility of these isolates to commonly used oral antibiotics for empiric therapy.
Main Methods:
- Aseptic samples of sinus mucosa and maxillary sinus aspirates were collected from 197 patients.
- Aerobic bacterial cultures were performed; anaerobic cultures were attempted in 143 patients.
- Susceptibility testing was conducted for various oral antibiotics against isolated bacterial strains.
Main Results:
- No anaerobic organisms were isolated.
- The most frequent isolates included coagulase-negative Staphylococcus species, Staphylococcus aureus, gram-negative bacilli, and Streptococcus species.
- Ciprofloxacin, trimethoprim/sulfamethoxazole, and cefuroxime axetil demonstrated superior activity compared to penicillin G, erythromycin, and tetracycline hydrochloride.
Conclusions:
- Aerobic bacteria are the primary pathogens in this cohort of chronic sinusitis patients.
- Current empiric antibiotic therapy for chronic sinusitis should consider the superior efficacy of newer agents like ciprofloxacin, trimethoprim/sulfamethoxazole, and cefuroxime axetil over older antibiotics.