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Updated: Aug 21, 2026

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
10:41

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

Published on: June 3, 2021

Cerebral blood flow velocity before and after cerebrospinal fluid drainage in infants with posthemorrhagic

Shigeru Nishimaki1, Yasuo Iwasaki, Hiroshi Akamatsu

  • 1Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. shigenis@med.yokohama-cu.ac.jp

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|September 28, 2004
PubMed

Insights

Measuring the resistive index in the anterior cerebral artery (RI-ACA) can help manage cerebrospinal fluid (CSF) drainage in infants with posthemorrhagic hydrocephalus. This objective measure guides effective CSF removal, improving infant care.

Area of Science:

  • Pediatric Neurology
  • Neurosurgery
  • Medical Imaging

Background:

  • Cerebrospinal fluid (CSF) drainage in infants with posthemorrhagic hydrocephalus is currently guided by subjective clinical assessments.
  • Objective methods are needed to standardize and optimize CSF drainage management.

Purpose of the Study:

  • To evaluate the utility of measuring the resistive index in the anterior cerebral artery (RI-ACA) for managing CSF drainage in infants with posthemorrhagic hydrocephalus.

Main Methods:

  • Pulsed Doppler sonography was used to measure RI-ACA in 7 infants with posthemorrhagic hydrocephalus.
  • Measurements were taken before and after CSF removal via lumbar or ventricular catheter reservoir punctures.

Main Results:

  • Elevated RI-ACA values (mean ± SD, 0.86 ± 0.04) significantly decreased (0.76 ± 0.05) after CSF removal.
  • CSF removal rates ranged from 5 to 10 mL/kg, with statistical significance (P <.0001).

Conclusions:

  • RI-ACA measurement shows promise as an objective tool for assessing CSF drainage efficacy.
  • This method may aid in determining the optimal volume of CSF to remove in hydrocephalic infants.
Abstract

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