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Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
Published on: January 4, 2011
Evaluation of normal corneas using the scanning-slit topography/pachymetry system
László Módis1, Achim Langenbucher, Berthold Seitz
1University of Debrecen, Medical and Health Science Centre, Department of Ophthalmology, Debrecen, Hungary. lmodis@dragon.klte.hu
Purpose:
To obtain anterior and posterior corneal shape, curvature, and thickness of normal human corneas. To provide a semiquantitative analysis of normal topography patterns of the anterior and posterior corneal surfaces.
Methods:
Eighty-eight healthy corneas of 44 normal subjects were analyzed using the scanning-slit topography/pachymetry system. Anterior and posterior elevation and mean power (central and steepest spherical and cylindrical) values and pachymetry data were determined. Right eye values were submitted for primary analysis; however, a comparison between right and left eyes was made in addition to test the possible reliability of the system.
Results:
There was no significant difference between right and left corneas in 28 evaluated parameters, except for anterior central cylindrical (P = 0.005) and steepest cylindrical (P = 0.017) mean power. The anterior central spherical mean power correlated inversely with the posterior central spherical mean power (r = -0.27, P = 0.04), and the anterior steepest spherical mean power value showed inverse correlation with the mean posterior steepest spherical value (r = -0.44, P = 0.001). The mean central thickness of the cornea was 593.7 +/- 54.19 microm at the center and was 578 +/- 50.53 microm at the thinnest point, which was localized in 41% (n = 18) of the cases in the inferotemporal quadrant. An oval-shaped pattern was the most characteristic feature of the anterior and posterior elevation, mean power, and pachymetry maps.
Conclusion:
Orbscan scanning-slit topography seems to be a reliable technique for the evaluation of normal corneas not only for anterior shape and curvature but also for a real pachymetry gradient recording.
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