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Updated: Aug 21, 2026

Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
Published on: April 24, 2020
Corneal endothelial cell damage after lens extraction using the fluid-based system compared to ultrasound
Helga P Sandoval1, Oday Al Sarraf, David T Vroman
1Magill Research Center for Vision Correction, Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA.
Purpose:
To compare the endothelial cell damage after lens removal using a fluid-based system to conventional ultrasound.
Methods:
Twenty human cadaver eyes were randomized to undergo phacoemulsification using either a fluid-based system or conventional ultrasound. After surgery, each corneoscleral button was removed, stained and damaged endothelial cells per square millimeter were assessed using light microscopy.
Results:
Fluid-based system mean damaged endothelial cells/mm was 60.2 +/- 24.1 compared with 60.4 +/- 42.6 when using conventional ultrasound (P = 0.248).
Conclusion:
The fluid-based system is as safe for the corneal endothelium as conventional ultrasound during cataract removal in human cadaver eyes.

