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Immunoglobulin E and systemic lupus erythematosus.

A M Atta1, C P Sousa, E M Carvalho

  • 1Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Geremoabo, s/n 40171-970 Salvador, Bahia, Brazil. ajatta@ig.com.br

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|September 28, 2004
PubMed
Summary

Systemic lupus erythematosus (SLE) patients can have elevated immunoglobulin E (IgE) and antinuclear IgE autoantibodies. However, this does not indicate an association with allergy or increased IgE antibodies to common allergens.

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Area of Science:

  • Immunology
  • Rheumatology
  • Allergy

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disorder marked by autoantibodies and immune complexes.
  • Previous studies suggested a link between SLE and Th2 immune responses or allergy.
  • The role of IgE in SLE pathogenesis remains unclear.

Purpose of the Study:

  • To investigate immunoglobulin E (IgE) levels and specific IgE autoantibodies in SLE patients.
  • To explore the presence of antinuclear IgE autoantibodies in SLE.
  • To assess the association between SLE and allergic sensitization.

Main Methods:

  • Serum IgE and IgE antibodies to aeroallergens were measured using automated enzyme-linked fluorescent assay.
  • Antinuclear IgE autoantibodies were detected via indirect immunofluorescence on HEp-2 cells.

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  • Serum anti-IgE IgG autoantibodies were quantified using immunocapture ELISA.

    • Main Results:

    • 33% of SLE patients exhibited elevated total IgE levels (median 394 IU/ml).
    • Only 9.5% of SLE patients had IgE antibodies to aeroallergens, unlike 100% of the atopic control group.
    • 81% of SLE patients showed antinuclear IgE autoantibodies, often with a fine speckled pattern.

    Conclusions:

    • Elevated IgE and antinuclear IgE autoantibodies can occur in SLE patients independently of clinical allergy.
    • The findings do not support a direct association between SLE and allergic sensitization to common aeroallergens.