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Related Experiment Videos

Element content and element correlations in Chinese human liver.

Peiqun Zhang1, Chunying Chen, Milena Horvat

  • 1Institute of High Energy Physics and Key Laboratory of Nuclear Analytical Techniques, Chinese Academy of Sciences, P.O. Box 918, 100039 Beijing, China.

Analytical and Bioanalytical Chemistry
|September 28, 2004
PubMed
Summary

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Instrumental neutron-activation analysis (INAA) quantified 19 elements in human liver samples. Results showed good inter-laboratory agreement and revealed correlations between elements, potentially linked to physiological functions.

Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Human Physiology

Background:

  • Human liver tissue is a critical matrix for assessing elemental exposure and physiological status.
  • Understanding elemental distribution and interrelationships is vital for human health research.
  • Lyophilized autopsy samples offer a stable matrix for long-term elemental analysis.

Purpose of the Study:

  • To quantify the concentrations of 19 elements in normal human liver samples.
  • To validate analytical methods through inter-laboratory comparisons.
  • To investigate sex-based differences and elemental correlations within human liver tissue.

Main Methods:

  • Instrumental Neutron-Activation Analysis (INAA) was employed for elemental quantification.
  • Lyophilized autopsy human liver samples (n=92) from normal subjects were analyzed.

Related Experiment Videos

  • Student's t-test and multivariate statistics were used for data analysis.

    • Main Results:

    • High agreement was achieved between two independent laboratories, confirming analytical reliability.
    • Significant sex-based differences in elemental content were observed for Ce, Co, Fe, La, Mo, and Zn.
    • Multivariate analysis revealed strong correlations among several elements (e.g., As-Fe, Cd-Zn, Cs-Rb).

    Conclusions:

    • The study provides reliable elemental concentration data for human liver tissue.
    • Observed elemental correlations suggest shared physiological roles or similar uptake/elimination pathways.
    • The findings contribute to a better understanding of human elemental homeostasis and potential toxicological implications.