Related Experiment Video
Updated: Aug 8, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Synchronous granulomatous cholecystitis and fibroelastosis of the gallbladder
Matthias Evert1, Albert Roessner, Christoph Röcken
1Institute of Pathology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany. matthias.evert@medizin.uni-magdeburg.de
Abstract:
We describe an unusual form of xanthogranulomatous cholecystitis in a 69-year-old man, with abundant intramural concrement formation and a local fibroelastosis of the adjacent interstitium and arteries. The gallbladder was obtained following resection of an adenocarcinoma of the gastro-esophageal junction without evidence of metastases. Only two cases of fibroelastosis of the gallbladder have previously been reported, and its pathogenesis is unknown. The influence of bile that leaked into the interstitium or a specific local tissue response to cytokines secreted by histiocytes are among the possible explanations for its development in our case.
Related Concept Videos
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
Chronic Inflammation: Introduction
Cirrhosis II: Pathophysiology
Cholecystitis

