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Related Experiment Videos

Embryonal risks in gestational diabetes mellitus.

Charles Savona-Ventura1, Miriam Gatt

  • 1Diabetic Pregnancy Joint Clinic, Department of Obstetrics-Gynaecology, St Luke's Teaching Hospital, Gwardamangia, Malta. saven@vol.net.mt

Early Human Development
|September 29, 2004
PubMed
Summary

Gestational diabetes does not increase the risk of congenital anomalies in newborns. This study found similar anomaly rates in infants born to mothers with gestational diabetes and those with normal glucose tolerance.

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Perinatal Medicine

Background:

  • Pre-existing diabetes in pregnancy is linked to higher risks of pregnancy loss and congenital anomalies.
  • Gestational diabetes mellitus (GDM) develops during pregnancy and historically, a previous infant anomaly was considered a risk factor for GDM.

Purpose of the Study:

  • To analyze the congenital anomaly rate in women diagnosed with gestational diabetes.
  • To compare these rates with those in women exhibiting normal glucose tolerance during pregnancy.

Main Methods:

  • Retrospective analysis of congenital anomaly rates.
  • Comparison between a cohort of women with gestational diabetes and a control group with normal glucose tolerance.

Main Results:

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  • The prevalence of congenital anomalies in infants born to mothers with gestational diabetes was 4.48%.
  • The prevalence of congenital anomalies in infants born to mothers with normal glucose tolerance was 4.54%.

Conclusions:

  • Gestational diabetes is not associated with an increased risk of teratogenesis (birth defects).
  • Unlike pre-existing diabetes, GDM does not appear to pose a significant teratogenic risk.