Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spinal stabilisation in Duchenne muscular dystrophy.

C S Galasko1, C Delaney, P Morris

  • 1Royal Manchester Children's Hospital, England.

The Journal of Bone and Joint Surgery. British Volume
|March 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recognition and expressed insight on Advanced Directives by patients with cancer.

Irish medical journal·2024
Same author

Temporal Characteristics of CSF-Venous Fistulas on Digital Subtraction Myelography.

AJNR. American journal of neuroradiology·2023
Same author

Infusion of Non-HLA-Matched Off-the-Shelf <i>Ex Vivo</i> Expanded Cord Blood Progenitors in Patients Undergoing Cord Blood Transplantation: Result of a Phase II Clinical Trial.

Frontiers in cell and developmental biology·2022
Same author

Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow.

Science (New York, N.Y.)·2021
Same author

Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients.

Scientific reports·2021
Same author

Impact of T Cell Repertoire Diversity on Mortality Following Cord Blood Transplantation.

Frontiers in oncology·2020

Surgical spinal stabilization significantly improved survival and lung function in patients with Duchenne muscular dystrophy. This intervention also halted scoliosis progression, offering better long-term outcomes compared to non-operative management.

Area of Science:

  • Orthopedic surgery
  • Neuromuscular disorders
  • Pulmonary function testing

Background:

  • Duchenne muscular dystrophy (DMD) is a progressive genetic disorder leading to muscle degeneration.
  • Spinal deformities, such as scoliosis, are common in DMD patients and can impair respiratory function.
  • Surgical intervention for spinal stabilization is an option for managing scoliosis in DMD.

Purpose of the Study:

  • To compare the outcomes of surgical spinal stabilization versus non-operative management in patients with Duchenne muscular dystrophy.
  • To assess the impact of spinal stabilization on survival, pulmonary function, and scoliosis severity.

Main Methods:

  • A cohort study comparing 32 patients who underwent surgical spinal stabilization with 23 who refused surgery.
  • Patients were monitored pre-operatively and at six-month intervals.

Related Experiment Videos

  • Key outcome measures included survival rates, forced vital capacity (FVC), peak expiratory flow rate (PEFR), and scoliosis severity.

    • Main Results:

    • The non-operated group experienced an annual deterioration of forced vital capacity by 8%, while the operated group maintained static lung function for 36 months post-surgery.
    • Spinal stabilization led to improved peak expiratory flow rate for up to five years.
    • Scoliosis progressed from 37 to 89 degrees in non-operated patients, whereas it improved from 47 to 34 degrees in the stabilized group over five years.
    • Significantly improved survival was observed in patients who underwent spinal stabilization.

    Conclusions:

    • Surgical spinal stabilization offers significant benefits for patients with Duchenne muscular dystrophy.
    • The procedure improves pulmonary function, halts scoliosis progression, and enhances long-term survival.
    • Spinal stabilization is a valuable therapeutic option for managing the complex care needs of DMD patients.