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Updated: Aug 21, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Acute leukemia with a very high leukocyte count: confronting a medical emergency
Navneet S Majhail1, Alan E Lichtin
1Department of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, USA.
Abstract:
From 5% to 30% of adult patients with acute leukemias present with hyperleukocytosis--very high white blood cell counts (> 100,000 cells/mm3)--and symptoms of leukostasis. These conditions are a medical emergency that needs prompt recognition and initiation of therapy to prevent respiratory failure or intracranial hemorrhage. Patients should be referred as soon as possible for induction chemotherapy and leukapheresis.
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