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HSV shedding.

S L Sacks1, P D Griffiths, L Corey

  • 1Viridae, Vancouver, Canada.

Antiviral Research
|September 29, 2004
PubMed
Summary
This summary is machine-generated.

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Herpes simplex virus (HSV) shedding is a major transmission risk. Daily antiviral therapy, like valaciclovir, significantly reduces HSV-2 transmission in couples.

Area of Science:

  • Virology
  • Infectious Diseases
  • Epidemiology

Background:

  • Viral shedding of herpes simplex virus (HSV) is frequent in infected individuals.
  • Asymptomatic shedding from multiple sites poses a significant transmission risk.
  • The relationship between shedding frequency, viral load, and transmission remains unclear.

Purpose of the Study:

  • To investigate the impact of suppressive antiviral therapy on HSV shedding and transmission.
  • To evaluate the efficacy of daily valaciclovir in reducing HSV-2 transmission among discordant couples.

Main Methods:

  • Utilized sensitive PCR techniques to quantify HSV shedding.
  • Assessed the effect of daily antiviral therapy on clinical and subclinical reactivation rates.
  • Conducted a study on heterosexual couples to measure HSV-2 transmission reduction with valaciclovir.

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Main Results:

  • PCR techniques reveal higher magnitude and frequency of HSV shedding than previously shown.
  • Suppressive antiviral therapy effectively reduces clinical and subclinical HSV reactivation.
  • Daily valaciclovir therapy significantly decreases HSV-2 transmission in monogamous discordant couples.

Conclusions:

  • HSV shedding is a critical factor in viral transmission.
  • Suppressive antiviral therapy is a viable strategy for preventing recurrent HSV infections.
  • Valaciclovir demonstrates efficacy in reducing HSV-2 transmission, offering a preventive measure for couples.