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Updated: Aug 21, 2026

Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy
Published on: October 24, 2017
Spontaneous vesicle formation and vesicle-tubular microstructure transition in aqueous solution of a poly-tailed
Wen-Jun Chen1, Li-Min Zhai, Gan-Zuo Li
1Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, Shandong University, Ji'nan 250100, People's Republic of China.
Abstract:
Spontaneous vesicle formation has been observed in aqueous mixtures of tri-(N-dodecyldimethylhydroxypropylammonium chloride) phosphate (PTA) and bis-(2-ethylhexyl) sulfosuccinate (Aerosol OT), which is supported by negative-staining TEM and dynamic light scattering. The range of vesicle formation in the PTA/AOT mixtures is wide and monodisperse vesicles are obtained. The vesicle diameter increases with the total surfactant concentration. Tubular microstructures, vesicle fusion, and vesicle-tubular microstructure transition have been also observed by negative-staining TEM. The vesicle formation mechanism is discussed from the viewpoint of molecular geometry, conformation, and the interaction between surfactant molecules.
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