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Updated: Aug 21, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
Hope for a broken heart?
Patrick Most1, Carmen Eicher, Mirko Völkers
1Division of Cardiology, Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. patrick_most@med.uni-heidelberg.de
Abstract:
Heart failure affects 23 million people worldwide and results from cardiac dysfunction characterized by decreased responsiveness to beta-adrenergic stimulation. A recent publication by W.J. Koch and colleagues highlights evidence for targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer to improve contractile function and beta-adrenergic responsiveness in failing human myocardium. This proof-of-concept study has great importance for future heart failure therapy because it provides evidence for the therapeutic effectiveness of betaARK1 inhibition in failing human myocardium.
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