Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does preoperative rofecoxib (Vioxx) decrease postoperative pain with laparoscopic cholecystectomy?

Mark C Horattas1, Steve Evans, Kimberly D Sloan-Stakleff

  • 1Department of Surgery, Akron General Medical Center, Northeastern Ohio Universities College of Medicine, 400 Wabash Ave., Akron, OH 44307, USA.

American Journal of Surgery
|September 29, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Clinically Interpretable AI System for Real-Time Quality Control of Transthoracic Echocardiography: Development, Validation, and Deployment.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026
Same author

Effectiveness of lay workers delivering behavioural activation for people with depression: systematic review and meta-analysis.

BJPsych open·2026
Same author

CHP/MMP2 dual-targeting soft mesoporous organosilica nanoparticles loaded with losartan for modulating cardiac fibrosis.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same author

Cannabis use increases surgical, medical, and psychosocial complications after lower extremity fracture fixation and shows compounded risk with concurrent nicotine use.

Scientific reports·2026
Same author

Multimodality Imaging in Myocarditis: Integrating Etiology, Diagnosis, and Risk Stratification.

Current cardiology reports·2026
Same author

Symptom trajectories and self-care patterns in chronic obstructive pulmonary disease and heart failure.

Heart & lung : the journal of critical care·2026
Same journal

Innovative management of Anterior Cutaneous Nerve Entrapment Syndrome (ACNES): A meta-analysis and introduction of a new robotic approach with patient-based algorithm.

American journal of surgery·2026
Same journal

Does the risk outweigh the benefit? Clot progression, recanalization & complications of anticoagulation therapy in acute pancreatitis with concomitant splanchnic vein thrombosis.

American journal of surgery·2026
Same journal

High and low body mass index and 90-day postoperative outcomes in patients with Crohn's disease undergoing abdominal surgery.

American journal of surgery·2026
Same journal

Women with firearm injuries: A multicenter mixed-methods study.

American journal of surgery·2026
Same journal

SBAS presidential address: A surgeon-scientist's journey from haptic science to digital performance metrics.

American journal of surgery·2026
Same journal

Using Dr. Google and AI to stay informed.

American journal of surgery·2026
See all related articles

Preemptive rofecoxib (Vioxx) significantly reduced narcotic needs and improved recovery for patients undergoing laparoscopic cholecystectomy. This study found fewer side effects like nausea in the rofecoxib group.

Area of Science:

  • Surgical analgesia
  • Pharmacology
  • Clinical trials

Background:

  • Investigating preemptive analgesia for laparoscopic cholecystectomy.
  • Evaluating rofecoxib (Vioxx) for pain management.
  • Prospective, randomized, double-blinded clinical trial design.

Purpose of the Study:

  • Assess the efficacy of preemptive rofecoxib in laparoscopic cholecystectomy.
  • Determine impact on postoperative pain and recovery.
  • Evaluate safety and side effect profile.

Main Methods:

  • 120 patients enrolled, 116 completed.
  • Randomized assignment to rofecoxib (50 mg) or placebo preoperatively.
  • Demographically similar groups with comprehensive data evaluation.

Related Experiment Videos

Main Results:

  • Significant reduction in postoperative narcotic analgesic requirements with rofecoxib.
  • Patients receiving rofecoxib reported less nausea and improved activity levels.
  • No complications observed with preemptive rofecoxib use.

Conclusions:

  • Preoperative rofecoxib may enhance postoperative recovery in selected patients.
  • Rofecoxib administration can decrease narcotic needs post-laparoscopic cholecystectomy.
  • Supports the use of preemptive rofecoxib for improved patient outcomes.