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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
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Generalized allergic reactions during anesthesia.

K Binkley1, A Cheema, G Sussman

  • 1Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.

The Journal of Allergy and Clinical Immunology
|March 1, 1992
PubMed
Summary
This summary is machine-generated.

Anesthesia allergy investigations found that over 50% of patients with adverse reactions showed evidence of thiopental allergy. No significant allergy to succinylcholine was detected in these patients.

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Area of Science:

  • Anesthesiology
  • Immunology
  • Clinical Allergy

Background:

  • Adverse reactions during anesthesia can be severe and life-threatening.
  • Identifying specific anesthetic agents responsible for allergic reactions is crucial for patient safety.

Purpose of the Study:

  • To investigate the immunological basis of generalized allergic reactions during anesthesia.
  • To determine the prevalence of allergy to thiopental and succinylcholine in patients with a history of anesthetic reactions.

Main Methods:

  • Skin testing with thiopental and succinylcholine.
  • Radioallergosorbent testing (RAST) for IgE antibodies to thiopental, succinylcholine, and latex.
  • Comparison of reactors with a control group without anesthetic reactions.

Main Results:

  • 17 out of 28 patients with anesthetic reactions had positive thiopental skin tests.
  • 14/28 reactors (50%) and 1/35 controls had elevated IgE thiopental RAST values.
  • IgE succinylcholine RAST was negative in all tested reactors; one reactor had a positive latex RAST.

Conclusions:

  • Evidence of allergy, particularly to thiopental, was found in over 50% of patients experiencing anesthetic reactions.
  • Thiopental is a likely cause of allergic reactions in a significant portion of these patients.
  • No evidence of succinylcholine allergy was identified in the study population.