Order and disorder in bacterial genomes
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Updated: Feb 21, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
1Unité Génétique des Génomes Bactériens, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France. erocha@abi.snv.jussieu.fr
Abstract:
The availability of sequenced bacterial genomes allows a deeper understanding of their organizational features that are related with fundamental cellular processes such as coordinated gene expression, chromosome replication and cell division. Nevertheless, recent genome comparisons and experimental work highlighted the fluidity of bacterial chromosomes, including genome rearrangements that imperil the selective features of chromosome order. As a result, the clash between elements generating rearrangements and chromosome organization is a classic case of evolutionary conflict.
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