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[Apolipoprotein levels in preeclamptic pregnancies]
S Kobayashi1, M Tanaka, K Masaki
1First Department of Obstetrics and Gynecology, Toho University School of Medicine, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi
|February 1, 1992
Summary
Pregnancy alters lipoprotein levels, with preeclampsia showing higher concentrations. Apolipoprotein B was significantly elevated and apolipoprotein E lower in preeclamptic pregnancies, suggesting their utility in evaluating this condition.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Obstetrics
Context:
- Lipoprotein levels increase during pregnancy, but contributing factors remain unclear.
- Preeclamptic pregnancies exhibit significantly higher lipoprotein concentrations compared to normal pregnancies.
- Apolipoproteins are key determinants of plasma lipoprotein metabolism and structure.
Purpose:
- To determine blood apolipoprotein AI, AII, B, and E levels in normal, non-pregnant, and preeclamptic states.
- To investigate the role of apolipoproteins in the altered lipoprotein metabolism observed during pregnancy and preeclampsia.
Summary:
- Apolipoprotein AI, AII, B, and E levels were measured in 12 normal pregnancies, 5 non-pregnancies, and 22 preeclamptic pregnancies using TIA methods.
- Results showed apolipoprotein B was significantly higher (p < 0.001) and apolipoprotein E significantly lower (p < 0.01) in preeclamptic pregnancies compared to normal pregnancies.
- Specific concentrations: Normal pregnancy (AI: 182.6, AII: 33.3, B: 128.6, E: 6.8 mg/dl); Non-pregnancy (AI: 135.6, AII: 30.8, B: 76.0, E: 4.4 mg/dl); Preeclampsia (AI: 181.0, AII: 33.2, B: 145.7, E: 5.8 mg/dl).
Impact:
- These findings suggest that apolipoprotein measurements can be valuable tools for evaluating preeclamptic pregnancies.
- Understanding apolipoprotein profiles may offer insights into the pathophysiology of preeclampsia.
- This research contributes to the diagnostic and prognostic understanding of pregnancy-induced hypertension disorders.