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Updated: Aug 8, 2026

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells
Published on: August 15, 2012
Persistent infection with primate foamy virus type 1 increases human immunodeficiency virus type 1 cell binding via a
Cecile Schiffer1, Charles-Henri Lecellier, Abdelkrim Mannioui
1Laboratoire d'Immunologie Cellulaire et Immunopathologie de l'EPHE, EMI-0013, Institut Universitaire d'Hématologie, Centre Hayem, Hôpital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris CEDEX 10, France.
Abstract:
We report that human T cells persistently infected with primate foamy virus type 1 (PFV-1) display an increased capacity to bind human immunodeficiency virus type 1 (HIV-1), resulting in increased cell permissiveness to HIV-1 infection and enhanced cell-to-cell virus transmission. This phenomenon is independent of HIV-1 receptor, CD4, and it is not related to PFV-1 Bet protein expression. Increased virus attachment is specifically inhibited by heparin, indicating that it should be mediated by interactions with heparan sulfate glycosaminoglycans expressed on the target cells. Given that both viruses infect similar animal species, the issue of whether coinfection with primate foamy viruses interferes with the natural course of lentivirus infections in nonhuman primates should be considered.
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