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Visualization by live-cell microscopy of disruption of ND10 during herpes simplex virus type 1 infection

Roger D Everett1, Alexandros Zafiropoulos

  • 1MRC Virology Unit, Church Street, University of Glasgow, Glasgow G11 5JR, Scotland, United Kingdom. r.everett@vir.gla.ac.uk

Journal of Virology
|September 29, 2004
PubMed

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Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...