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Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy
N C K Tan1, S E Heron, I E Scheffer
1Epilepsy Research Centre and Department of Medicine (Neurology), University of Melbourne, USA.
Abstract:
Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.
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